Effect of emoxipine on cytotoxicity of peripheral blood mononuclears under cultivation with cytarabine and cyclocytidine

Taking into account the special role of oxidative stress that increases during cancer chemotherapy, effect antioxidant emoxipine on peripheral blood mononuclears was studied under conditions simulate cytotoxic effects antimetabolites a number modified cytidine nucleosides in relation to tumor cell line K562. Lymphoid cells were also source for subsequent modelling immune response cancer. It found neither themselves nor their combination with caused changes IL-2-stimulated cytotoxicity lymphoid K562 line. A study expression CD107a marker showed significant stimulating 1 µmol/L citarabine activation subpopulations T-lymphocytes (CD3+ ) and CD8+ ).